Hesperetin

Base Information

  • PRODUCT:Hesperetin
  • CAS.:520-33-2
  • MF:C16H14O6
  • Molecular Weight:302.284
  • Purity:99%

Product Details

CAS: 520-33-2

MF: C16H14O6

Appearance: Beige to Light Brown Crystalline Solid

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  • Molecular Formula:C16H14O6
  • Molecular Weight:302.284
  • Appearance/Colour:Beige to Light Brown Crystalline Solid 
  • Vapor Pressure:2.45E-14mmHg at 25°C 
  • Melting Point:230-232 °C 
  • Refractive Index:-4 ° (C=1.8, EtOH) 
  • Boiling Point:586.2 °C at 760 mmHg 
  • PKA:7.49±0.40(Predicted) 
  • Flash Point:223 °C 
  • PSA:96.22000 
  • Density:1.458 g/cm3 
  • LogP:2.51850 

Hesperetin(Cas 520-33-2) Usage

Purification Methods

Crystallise it from EtOAc or ethanol. The natural S(-) form crystallises from EtOH and has m 216-218o and [] D -37.6o (c 2, EtOH). Note that C2 is chiral. [Beilstein 18 II 204, 18 III/IV 3215, 18/5 V 214.]

Definition

ChEBI: Hesperetin is a trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position. It has a role as an antioxidant, an antineoplastic agent and a plant metabolite. It is a monomethoxyflavanone, a trihydroxyflavanone, a member of 3'-hydroxyflavanones and a member of 4'-methoxyflavanones. It is a conjugate acid of a hesperetin(1-).

InChI:InChI=1/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3/t14-/m0/s1

520-33-2 Relevant articles

Design and synthesis of 7-O-1,2,3-triazole hesperetin derivatives to relieve inflammation of acute liver injury in mice

Zheng, Yan,Zhang, Yi-long,Li, Zeng,Shi, Wen,Ji, Ya-ru,Guo, Ya-Hui,Huang, Cheng,Sun, Guo-ping,Li, Jun

, (2021/01/25)

Based on the previous research results o...

Enhanced antioxidant, anti-inflammatory and α-glucosidase inhibitory activities of citrus hesperidin by acid-catalyzed hydrolysis

Lu, Shengmin,Xing, Jianrong,Zheng, Meiyu

, (2020/08/05)

Hesperidin hydrolysates (HHS) was produc...

Hesperetin as an inhibitor of the snake venom serine protease from Bothrops jararaca

dos Santos, Roney Vander,Grillo, Giovanna,Fonseca, Henrique,Stanisic, Danijela,Tasic, Ljubica

, p. 64 - 72 (2021/05/13)

The majority (90%) of the snakebite enve...

Discovery of Novel Bacterial Chalcone Isomerases by a Sequence-Structure-Function-Evolution Strategy for Enzymatic Synthesis of (S)-Flavanones

Bornscheuer, Uwe T.,Brückner, Stephan I.,Gei?ler, Torsten,Gross, Egon,Hartmann, Beate,Ley, Jakob P.,Meinert, Hannes,R?ttger, Carsten,Schuiten, Eva,Yi, Dong,Zirpel, Bastian

supporting information, p. 16874 - 16879 (2021/07/06)

Chalcone isomerase (CHI) is a key enzyme...

520-33-2 Process route

hesperetin 7‐O‐β‐D‐glucopyranoside

hesperetin 7‐O‐β‐D‐glucopyranoside

β-D-glucose
492-61-5

β-D-glucose

hesperetin
520-33-2,41001-90-5,69097-99-0

hesperetin

Conditions
Conditions Yield
With water; Enzymatic reaction;
4<sup>G</sup>-α-D-glucopyranosyl hesperidin
161713-86-6

4G-α-D-glucopyranosyl hesperidin

hesperidin
520-26-3

hesperidin

hesperetin
520-33-2,41001-90-5,69097-99-0

hesperetin

Conditions
Conditions Yield
With small intestine homogenate of rat; at 37 ℃; for 4h; Title compound not separated from byproducts.;

520-33-2 Upstream products

  • 520-26-3
    520-26-3

    hesperidin

  • 161713-86-6
    161713-86-6

    4G-α-D-glucopyranosyl hesperidin

  • 520-33-2
    520-33-2

    (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone

  • 67-56-1
    67-56-1

    methanol

520-33-2 Downstream products

  • 70987-96-1
    70987-96-1

    5-hydroxy-3′4′7-trimethoxy flavanone

  • 520-33-2
    520-33-2

    (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone

  • 6274-73-3
    6274-73-3

    (S)-5,7-diacetoxy-2-(3-acetoxy-4-methoxy-phenyl)-chroman-4-one

  • 6033-54-1
    6033-54-1

    (-)-hesperetin oxime

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